Safrole (293294), isosafrole (293291), piperonal (293293), and BMK—1-(1,3-benzodioxol-5-yl)propan-2-one (293292)—are DEA List I or List II chemicals used in illicit drug synthesis. Importers must hold a valid DEA registration and, in most cases, obtain an import permit before shipment. Tetrahydrocannabinols (293295) are Schedule I controlled substances subject to separate DEA import authorization.

Sucralose is classified under subheading 293214 as a heterocyclic compound with an unfused furan ring, rather than under the sugar or food-preparation headings, because its classification follows chemical structure. As a food additive, it is subject to FDA review at entry; importers should ensure the product meets FDA food-additive specifications and that the foreign manufacturer is registered with FDA.