Yes — food-grade casein intended for use as a food ingredient is subject to FDA oversight as a food additive or GRAS substance. Importers should ensure the product meets applicable food safety standards and be prepared for FDA examination at entry. Industrial-grade casein used in adhesives or coatings is not subject to food-additive requirements but must still be accurately declared.

Casein glue is explicitly named within heading 3501 and classifies under subheading 350190 alongside caseinates and other casein derivatives. It does not fall under the adhesives headings in Chapter 35 that cover prepared glues and adhesives more broadly, because the specific mention of casein glue in 3501 takes precedence under the GRI specificity rule.