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HSChapter 29
U.S. imports of polypeptide, protein, and glycoprotein hormones and derivatives (nesoi) (HS 293719) totaled $122.1M in June 2026, traded with 25 countries.
Importers of Polypeptide, Protein, and Glycoprotein Hormones and Derivatives (NESOI) paid $53K in duties in June 2026 — an effective duty rate of 10% on $528K in dutiable value, based on actual customs collections rather than the published tariff schedule.
Last updated: June 2026 dataPolypeptide, protein, and glycoprotein hormones not elsewhere specified — including gonadotropins, thyrotropin, erythropoietin, and related recombinant biologics — are classified under tariff line 2937190000. These are among the most complex pharmaceutical imports from a regulatory standpoint: many are approved biologics subject to FDA's Center for Biologics Evaluation and Research (CBER) or Center for Drug Evaluation and Research (CDER) oversight, and biosimilar versions face additional interchangeability determinations. The NESOI designation means importers should confirm that a more specific heading does not apply before using this line.
AI-written summary of the official U.S. Census Bureau trade figures on this page — verify before relying on it.
The NESOI rule requires that 293719 be used only when no more specific heading applies. Somatotropin and its analogues belong under 293711; insulin and its salts under 293712. All other polypeptide, protein, and glycoprotein hormones — such as gonadotropins, erythropoietin, or thyrotropin — fall under 2937190000. When a novel biologic's classification is uncertain, a binding ruling request to CBP is the most reliable approach.
No — HTS classification is based on the chemical nature of the product, not its regulatory approval status. A biosimilar erythropoietin and the reference biologic both classify under 2937190000. However, biosimilar status is highly relevant to FDA admissibility: the product must reference an approved biosimilar application, and interchangeability designations affect substitution rights in the US market.
| Country | Imports | Exports | Balance |
|---|---|---|---|
| ITALY | $192K | $1.4B | +$1.4B |
| GERMANY | $1.4M | $292.3M | +$290.9M |
| IRELAND | $60.6M | $664K | -$59.9M |
| FRANCE | $9K | $52.5M | +$52.5M |
| SWITZERLAND | $30.0M | $7K | -$30.0M |
Monthly import values over time
HS10 import codes under this HS6 parent. Source: U.S. Harmonized Tariff Schedule.
| Code | Description | Import Value | Effective Tariff % | Dutiable Share | Duty Collected |
|---|---|---|---|---|---|
| 2937190000 | POLYPEPTIDE, PROTEIN & GLYCOPROTEIN HORMONES,NESOI | $122.1M | 0.04% | 0.43% | $53K |
POLYPEPTIDE, PROTEIN & GLYCOPROTEIN HORMONES,NESOI
HS10 export codes under this HS6 parent. Source: U.S. Schedule B export classification.
| Code | Description | Export Value |
|---|---|---|
| 2937190000 | POLYPEPTIDE, PROTEIN & GLYCOPROTEIN HORMONES,NESOI | $1.8B |
POLYPEPTIDE, PROTEIN & GLYCOPROTEIN HORMONES,NESOI
5.4M gm
NUCLEIC ACIDS & SALTS; OTHER HETEROCYCLIC CMP, NES
HS 293499
CMPDS CONT AN UNFUSED PYRIDINE RING ETC NESOI
HS 293339
BENZENE
HS 290220
HETEROCYCLIC COMP W NITROGEN HETERO-ATM ONLY NESOI
HS 293399
HETEROCYCLIC COMP WITH UNFUSED PYRAZOLE RING NESOI
HS 293319
SULPHONAMIDES, NESOI
HS 293590
Supplier Network
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| State | Imports | Exports | Balance |
|---|---|---|---|
| Indiana | $60.7M | $1.7B | +$1.6B |
| Puerto Rico | -- | $36.5M | +$36.5M |
| Massachusetts | $5.3M | $13.6M | +$8.4M |
| Port | Imports | Exports | Balance |
|---|---|---|---|
| CHICAGO, IL | $66.7M | $1.7B | +$1.6B |
| SAN JUAN INTERNATIONAL AIRPORT, PR | -- | $36.5M | +$36.5M |
| JFK INTERNATIONAL AIRPORT, NY | $24.9M | $203K | -$24.7M |