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SITCSection 5
U.S. imports of vegetable alkaloids (not elsewhere specified), their salts, and derivatives (SITC 54149) totaled $22.0M in April 2026, traded with 16 countries.
Last updated: April 2026 dataA residual catch-all for plant-derived alkaloids not captured by more specific SITC headings, this category encompasses a wide range of compounds — from colchicine (used in gout treatment) to vinblastine and vincristine (oncology APIs derived from Catharanthus roseus) — each with distinct pharmacological profiles and regulatory requirements. FDA cGMP rules apply to pharmaceutical-grade imports, and some compounds in this grouping may also be subject to DEA scheduling or CITES controls depending on the source plant species. Importers must identify the specific alkaloid to determine the correct HTS classification and applicable agency review.
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The importer should check the DEA's list of scheduled substances and List I/II chemicals against the specific compound being imported. Many vegetable alkaloids are not DEA-controlled, but some — such as certain opium-adjacent compounds — may be. A DEA regulatory counsel or licensed customs broker with pharmaceutical experience can assist in making this determination before the shipment is arranged.
Yes. If the source plant is listed under CITES Appendix I or II, the extracted alkaloid may require CITES export permits from the country of origin and import permits from the US Fish and Wildlife Service, in addition to FDA drug substance requirements. This is particularly relevant for alkaloids sourced from rare or endangered botanical species.
| Country | Imports | Exports | Balance |
|---|---|---|---|
| CHINA | $7.1M | $65K | -$7.0M |
| SWITZERLAND | $4.8M | $8K | -$4.8M |
| INDIA | $4.3M | $331K | -$4.0M |
| UNITED KINGDOM | $3.2M | -- | -$3.2M |
| ITALY | $1.4M | -- | -$1.4M |
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Monthly import values over time