U.S. imports of Theophylline, Aminophylline, Their Derivatives, and Salts (SITC 54145) totaled $43K in August 2026, imported from 6 countries.
Theophylline, Aminophylline, Their Derivatives, and Salts imports of $43K in August 2026 ran 81% below the year-to-date monthly average of $232K.
Last updated: August 2026 dataTheophylline — a methylxanthine bronchodilator chemically related to caffeine — and its ethylenediamine complex aminophylline are established APIs used in the treatment of asthma and chronic obstructive pulmonary disease. Both compounds have narrow therapeutic indices, making pharmaceutical-grade purity and consistent specification critical for downstream drug manufacturers. FDA cGMP requirements apply to imported bulk drug substances, and importers should verify that foreign suppliers hold current FDA facility registration and have not been placed on import alert.
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3 import shipments a month
Because theophylline's toxic dose is close to its therapeutic dose, even minor impurities or potency deviations in the bulk API can create patient safety risks in finished drug products. FDA inspectors pay close attention to analytical method validation and impurity profiles when reviewing cGMP compliance at foreign theophylline manufacturing sites.
At the SITC level they share a single heading, but the HTS schedule may distinguish them at the 10-digit level. Importers should confirm the correct HTS subheading with a licensed customs broker, as the specific compound and its salt form can affect duty treatment and statistical reporting.
Basic heading 451 of 465 in section 5
Basic heading 54145 · $43K of $27.5B
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Imports · August 2026
origin
South Africa and Germany together supply 93% of it.
customs district
Census does not publish district detail for this classification system.
destination
Census does not publish state detail for this classification system.
entry
Census does not publish port detail for this classification system.
ImportsExports
Imports
$43KYoY · free account
Exports
$35KYoY · free account
12-mo low · imports
Low · free accountOver the twelve months to August 2026, the U.S. imported $2.9M of Theophylline, Aminophylline, Their Derivatives, and Salts.
Fewer than 6 of the last 12 months reported trade, or the latest month was under $500K; the trend chart is not shown for thin series.
Through August 2026 · exports 11 of 12 months reported. Source: U.S. Census Bureau.