SITCSection 5
U.S. imports of glycosides & their salts, ethers, esters and derivatives (SITC 54161) totaled $33.9M in April 2026, traded with 28 countries.
Importers of Glycosides & Their Salts, Ethers, Esters and Derivatives paid $1.2M in duties in April 2026 — an effective duty rate of 3.8% on $32.3M in dutiable value, based on actual customs collections rather than the published tariff schedule.
Last updated: April 2026 dataNatural glycosides — including cardiac glycosides such as digoxin precursors, as well as synthetically reproduced equivalents — and their salts, ethers, esters, and other chemical derivatives are traded under this heading primarily as pharmaceutical intermediates and botanical-derived APIs. The distinction between naturally extracted and synthetically reproduced glycosides is commercially significant: sourcing, quality specifications, and regulatory documentation differ substantially between plant-extracted and fermentation- or synthesis-derived material. FDA entry review applies to imported pharmaceutical-grade glycoside materials, and importers should be prepared to provide certificates of analysis and facility registration data.
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No — SITC 54161 explicitly covers both naturally occurring glycosides and those reproduced by synthesis, as well as their salts, ethers, esters, and derivatives. However, origin (natural vs. synthetic) can affect FDA regulatory pathway, pharmacopeial specifications, and supplier documentation requirements, so importers should clearly identify the production method in their entry documentation.
Importers generally need to provide a certificate of analysis confirming identity and purity, evidence of FDA facility registration for the foreign manufacturer, and a commercial invoice specifying the chemical name and CAS number. If the glycoside is a controlled substance precursor, additional DEA documentation may be required.
| Country | Imports | Exports | Balance |
|---|---|---|---|
| CHINA | $22.8M | $714K | -$22.0M |
| MALAYSIA | $4.0M | $3K | -$4.0M |
| CANADA | $18K | $2.5M | +$2.5M |
| KOREA, SOUTH | $1.6M | $48K | -$1.5M |
| CHILE | $1.2M | $3K | -$1.2M |
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Monthly import values over time