FDA defines natural flavors under 21 CFR 101.22 as those derived from plant or animal sources through specified processes, while artificial flavors are synthesized chemically. The distinction affects both label declarations and, in some cases, the applicable food additive petition or GRAS status required for market entry.

The underlying FDA food safety and additive compliance requirements apply regardless of end-use channel. However, retail-packaged syrups require full nutrition labeling under 21 CFR Part 101, while bulk foodservice formats may qualify for modified labeling exemptions — importers should confirm the applicable format with their regulatory counsel.