Yes. Norephedrine is a List I chemical under the Controlled Substances Act, placing it in the same regulatory tier as ephedrine and pseudoephedrine. Importers must hold DEA registration, obtain a shipment-specific import permit, and comply with advance notification and recordkeeping requirements. The DEA and CBP coordinate inspections for all three alkaloids at the border.

Heading 300343 is specific to norephedrine and its salts, while heading 300349 captures all other alkaloid-containing medicaments not elsewhere specified. If a bulk medicament contains norephedrine as its active alkaloid, it should be classified under 300343 rather than the residual 300349 line. Correct identification of the specific alkaloid is therefore essential to proper classification and to triggering the correct DEA permit category.