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HSChapter 29
U.S. exports of dextropropoxyphene (inn) and its salts (HS 292214) totaled $33K in December 2025, traded with 1 country.
Dextropropoxyphene — marketed historically as propoxyphene — is an opioid analgesic that was withdrawn from the US market by FDA in 2010 due to cardiac safety concerns, meaning current imports under this heading (2922140000) are almost exclusively for research, reference standard, or export-manufacturing purposes rather than domestic pharmaceutical use. As a DEA Schedule IV controlled substance, any importation requires a DEA import permit and strict chain-of-custody documentation. Switzerland is the sole identified supplier in current US trade data, consistent with the compound's niche role as a reference standard or intermediate in Swiss fine-chemical production. Importers must coordinate DEA, FDA, and CBP requirements simultaneously, as the compound's withdrawn-drug status adds a layer of regulatory complexity beyond standard controlled-substance procedures.
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Yes, but only for very limited purposes. FDA's 2010 withdrawal removed propoxyphene-containing drug products from the US market, but importation of the bulk API for research, analytical reference standards, or re-export manufacturing remains possible with appropriate DEA Schedule IV import authorization and FDA oversight. Importers must clearly document the intended use and ensure the receiving facility holds the necessary DEA registration for the specific activity.
Switzerland's dominance reflects its role as a global center for fine-chemical and pharmaceutical reference standard production. Given the extremely limited legitimate US demand for dextropropoxyphene post-withdrawal, the trade flow is likely confined to small-volume reference standard or research-grade material from Swiss specialty chemical manufacturers. This concentration in a single source country means any supply disruption would directly affect the small pool of authorized US importers.
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Monthly import values over time
| Country | Imports | Exports | Balance |
|---|---|---|---|
| MEXICO | -- | $27K | +$27K |
| SWITZERLAND | -- | -- | -- |
HS10 export codes under this HS6 parent, each with its own page. Source: U.S. Schedule B export classification.
| Code | Description | Export Value |
|---|---|---|
| 2922140000 | DEXTROPROPOXYPHENE (INN) AND ITS SALTS | $27K |
NUCLEIC ACIDS & SALTS; OTHER HETEROCYCLIC CMP, NES
HS 293499
POLYPEPTIDE PROTEIN& GLYCOPROTEIN HORMONES &DERIV
HS 293719
CMPDS CONT AN UNFUSED PYRIDINE RING ETC NESOI
HS 293339
BENZENE
HS 290220
HETEROCYCLIC COMP W NITROGEN HETERO-ATM ONLY NESOI
HS 293399
HETEROCYCLIC COMP WITH UNFUSED PYRAZOLE RING NESOI
HS 293319
| Port | Imports | Exports | Balance |
|---|---|---|---|
| LAREDO, TX | -- | $27K | +$27K |