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HSChapter 30
U.S. imports of cell cultures, whether or not modified (nesoi) (HS 300259) totaled $3.2M in April 2026, traded with 30 countries.
Last updated: April 2026 dataModified and unmodified cell cultures not classified under the dedicated cell-therapy heading serve as critical upstream inputs for vaccine production, biopharmaceutical manufacturing, and research applications. The United Kingdom and Germany are the leading US suppliers, with Switzerland and China also significant sources — a supplier mix that spans both highly regulated European GMP environments and lower-cost Asian production. Imported cell cultures may be subject to FDA review as biologics or research materials depending on their intended use, and APHIS may assert jurisdiction over cultures derived from animal or plant material. Classification between this heading (3002590000) and related Chapter 38 research-reagent provisions can be a recurring customs dispute for importers.
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The key distinction is whether the cell culture is intended for therapeutic, prophylactic, or diagnostic use in humans or animals (Chapter 30) versus purely industrial or research use (Chapter 38). FDA-regulated biologics and products destined for clinical use generally belong in Chapter 30, while research-grade cell lines without a therapeutic indication may fall in Chapter 38. Importers should document the intended use clearly and consult a licensed customs broker, as CBP has issued binding rulings on this boundary.
Yes. Cell cultures derived from animal tissue may be subject to USDA APHIS review under the Animal Health Protection Act, particularly if there is a risk of introducing foreign animal disease agents. Importers may need to obtain an APHIS import permit and provide documentation of the source species, country of origin, and any pathogen-inactivation steps. This requirement is separate from FDA's biologics review.
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Monthly import values over time
| Country | Imports | Exports | Balance |
|---|---|---|---|
| GERMANY | $708K | $1.5M | +$822K |
| CHINA | $356K | $1.2M | +$843K |
| UNITED KINGDOM | $917K | $504K | -$414K |
| JAPAN | $396K | $439K | +$43K |
| CANADA | $68K | $414K | +$346K |